[email protected]

BMP9-induced osteoblastic differentiation requires

Genetic disruption of Notch pathway severely impairs BMP9-induced osteogenic differentiation and ectopic bone formation from MSCs. Furthermore, while BMP9-induced eion of early-responsive genes is not affected by defective Notch signaling, BMP9 upregulates the eion of Notch receptors and ligands at the intermediate stage of osteogenic differentiation. CCAAT/enhancer binding protein homologous protein Dec 18, 2003 · Notch 1 impairs osteoblastic cell differentiation. Sciaudone M , Gazzerro E , Priest L , Delany AM , Canalis E Endocrinology , 144(12):5631-5639, 04 Sep 2003

Crucial role of Notch signaling in osteogenic

Jun 01, 2014 · The Notch signaling pathway is highly conserved and associated with selfrenewal potential and cellfate determination. Recently, several studies have focused on the relationship between Notch signaling and osteogenic differentiation. However, the precise mechanisms underlying this relationship are largely unknown. Effect of radiation on the Notch signaling pathway in

  • IntroductionMaterials and MethodsResultsDiscussionAcknowledgementsRadiation therapy is an important and effectivemethod for the treatment of tumors. However, this widely usedtreatment increases the occurrence of long-term side effects causedby radiation damage to normal tissues near the tumor. Sequelae inthe skeleton and bone marrow can occur as late consequences forsurvivors following radiation therapy of cancer (1). Bones within the irradiated volumecan absorb radiation doses, resulting in an increased fracture risk(26). In addition to bone fracture,demineralizatioInhibition of Human Dental Pulp Stem Cell Differentiation Mar 01, 2008 · Moreover, over-eion of the constitutively activated Notch1 intracellular domain (Notch-ICD) also inhibited odontoblastic differentiation of DPSCs. Taken together, our results demonstrate that Notch signaling can inhibit the odontoblastic differentiation of DPSCs. Engineered Biomaterials Control Differentiation - cellFeb 27, 2014 · Upon determining context-specific effects of Notch activation on cardiac differentiation, we sought to determine the role of Notch activation in guiding the development of terminally differentiated cardiomyocytes. hESC-derived MYH7+ cardiomyocytes exhibit significant increases in mRNA levels of the Notch ligand, JAGGED-1, and the Notch signaling target gene, HES1, compared to an

    OSM is overeed in knee osteoarthritis and Notch

    • IntroductionMaterials and MethodsResultsDiscussionOsteoarthritis (OA) is a musculoskeletal disorder(1) accounting for 3% of totalnumber of years of living with a disability, particularly in theelderly (2,3). Knee OA is the most prevalent type ofOA (4). It is characterized bythe progressive degeneration and structural disorder of thearticular cartilage, resulting in loss of joint space, accompaniedby marginal and central new bone formation (5). Over the past 30 years, a number of cytokines havebeen identified to be involved in OA, particularly interleukin(IL)-1 and IL-6 (6Characterization of Notch Signaling During Osteogenic Dec 01, 2016 · Abstract. ORIGINAL RESEARCH ARTICLE 2652 Journal of Journal of Cellular Cellular Physiology Physiology Characterization of Notch Signaling During Osteogenic Differentiation in Human Osteosarcoma Cell Line MG63 1 1 1 1 ALESSIA ONGARO, * AGNESE PELLATI, LEILA BAGHERI, PAOLA RIZZO, 2 1 1 CRISTIANA CALICETI, LEO MASSARI, AND MONICA DE MATTEI Department Parathyroid hormone stimulates eion of the Notch Sep 01, 2006 · Eion of the Notch ligand Jagged1 has been detected in osteoblastic cells in vivo and in vitro , , , , , , and during bone regeneration . Notch signaling has been implicated in osteogenesis , , , . Controversy exists regarding the role of Notch signaling in osteoblastic differentiation. Role of the Ram Domain and Ankyrin Repeats on Notch Dec 04, 2009 · Introduction:Notch receptors play a role in osteoblast differentiation. Activation of Notch results in its cleavage and the release of its intracellular domain (NICD), which interacts with the CBF1/RBPJ, Suppressor of Hairless, Lag1 (CSL) family of transcription factors.

      Notch 1 Impairs Osteoblastic Cell Differentiation

      In the presence of bone morphogenetic protein-2 (BMP-2), ST-2 cells differentiated toward osteoblasts forming mineralized nodules, and Notch 1 opposed this effect and decreased the eion of osteocalcin, type I collagen, and alkaline phosphatase transcripts and 2 FosB protein. Further, NotchIC decreased Wnt/-catenin signaling.